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The appropriate time for a perianesthesia nurse to remove a laryngeal mask airway (LMA) is when the patient can open their mouth on command. This indicates that the patient has regained sufficient muscle tone and consciousness for effective airway protection. The ability to open the mouth is an essential indicator suggesting that the patient is adequately responding and gaining control over their airway, which can help prevent potential complications, such as airway obstruction or aspiration.

While other options may suggest varying levels of responsiveness, they do not directly correlate to the necessary muscle tone and airway reflexes required for safe extubation. For instance, suctioning an airway does not indicate that the patient is ready for extubation; it is merely a part of airway management to clear any secretions. Similarly, an ability to open eyes is a sign of consciousness, but it does not confirm that the patient has regained complete neuromuscular function, which is critical in ensuring a safe airway. Finally, the ability to swallow can be a positive sign of recovery; however, it also does not necessarily reflect readiness for LMA removal as this can vary among patients.

Therefore, the ability to open the mouth on command serves as a strong indicator of the patient regaining adequate airway control,